Tag » Immunology

Combining talimogene laherparepvec with immunotherapies in melanoma and other solid tumors

Abstract

              <p>Talimogene laherparepvec is a first-in-class intralesional oncolytic immunotherapy. In a recent Phase III trial (OPTiM), talimogene laherparepvec significantly improved durable response rate compared with subcutaneous granulocyte–macrophage colony-stimulating factor (GM-CSF). 213 kata lagi
By Alexandros G. Sfakianakis

Expression of VISTA correlated with immunosuppression and synergized with CD8 to predict survival in human oral squamous cell carcinoma

Abstract

              <p>V-domain Ig suppressor of T cell activation (VISTA), a novel immune checkpoint regulatory molecule, suppresses T cell mediated immune responses. The aim of the present study was to profile the immunological expression, clinical significance and correlation of VISTA in human oral squamous cell carcinoma (OSCC). 215 kata lagi
By Alexandros G. Sfakianakis

The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study

Abstract

Background

Mono- and polysensitization are different IgE-mediated allergic phenotypes in children. Allergic sensitization is associated with both allergic asthma and allergic rhinitis, however, associations between the sensitization pattern and particularly polysensitization with asthma and rhinitis remains poorly studied in adults. 242 kata lagi

By Alexandros G. Sfakianakis

Recovery from desensitization of IgE-dependent responses in human lung mast cells

Abstract

Background

Clinical desensitization and oral food immunotherapy are therapeutic interventions that allow individuals who react adversely to an allergen (drug or food) to be made tolerant to the allergen. 229 kata lagi

By Alexandros G. Sfakianakis

The Vienna Biocenter (VBC) PhD Programme in Life Sciences #Vienna, Austria #1 March 2017

The VBC PhD Programme is a research-oriented educational programme that aims to support the scientific training of young graduates. Students learn through original (supervised) research projects; at the end of their studies they will be able to carry out independent research projects. 198 kata lagi

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Effects of structured patient education in adult atopic dermatitis – multi-center randomized controlled trial

Publication date: Available online 24 February 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Annice Heratizadeh, Thomas Werfel, Andreas Wollenberg, Susanne Abraham, Sibylle Plank-Habibi, Christina Schnopp, Michael Sticherling, Christian Apfelbacher, Tilo Biedermann, Kristine Breuer, Isabel Fell, Regina Fölster-Holst, Guido Heine, Jennifer Grimm, Lars Hennighausen, Claudia Kugler, Imke Reese, Johannes Ring, Knut Schäkel, Jochen Schmitt, Kurt Seikowski, Esther von Stebut, Nicola Wagner, Anja Waßmann-Otto, Ute Wienke-Graul, Elke Weisshaar, Margitta Worm, Uwe Gieler, Joerg Kupfer… 275 kata lagi

By Alexandros G. Sfakianakis

Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis

Background

The unconventional toll-like receptor (TLR) CD180 is implicated in chronic inflammatory diseases; however, its role in chronic rhinosinusitis (CRS) has yet to be investigated. Here we study the expression of CD180, its homologue TLR4 and myeloid differentiation factor 1 (MD1) on mucosal and systemic immune cell populations in relation to serum immunoglobulin G (IgG) levels. 154 kata lagi

By Alexandros G. Sfakianakis